Why is dextran used as a plasma expander?
Dextran is used as a plasma expander primarily due to its ability to increase blood volume and improve hemodynamic stability in patients who have experienced significant blood loss or low plasma volume. Here are some key reasons for its use:
1. Colloid Properties:
Dextran is a colloid, meaning it can draw water into the bloodstream from surrounding tissues by creating an oncotic pressure that helps retain fluid within the vascular space. This increases overall blood volume.
2. Volume Expansion:
It effectively expands plasma volume, which can be crucial in conditions like shock, severe bleeding, or during surgeries when maintaining blood pressure and circulation is vital.
3. Stability and Compatibility:
Dextran is generally well-tolerated and compatible with most blood components. It does not typically cause significant allergic reactions or transfusion-related complications.
4. Ease of Administration:
Dextran solutions can be administered intravenously, making them easy to use in emergency settings to quickly restore blood volume.
5. Support for Microcirculation:
In addition to expanding plasma volume,
dextran may help improve microcirculatory flow, which can enhance tissue perfusion and oxygen delivery.
However, it’s important to note that while dextran can be effective, its use may be limited in certain situations due to potential side effects, such as allergic reactions or interference with blood typing. Therefore, careful consideration is required when using dextran as a plasma expander.