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The half-life of tirofiban elimination is approximately 2 hours. Here are some key points about tirofiban's pharmacokinetics:

1. Short half-life: 
Tirofiban has a relatively short half-life of about 2 hours in patients with normal renal function.

2. Renal elimination: 
The drug is primarily eliminated by the kidneys. About 65-75% of an administered dose is excreted in urine, mostly unchanged.

3. Plasma clearance: 
The plasma clearance of tirofiban is around 250 mL/min in patients with normal renal function.

4. Effect of renal impairment: 
In patients with moderate renal impairment (creatinine clearance 30-60 mL/min), the plasma clearance of tirofiban is reduced by about 40%, and the half-life is increased to about 3 hours.

5. Severe renal impairment: 
In patients with severe renal impairment (creatinine clearance <30 mL/min), the plasma clearance is reduced by about 50%, and the half-life is increased to about 4 hours.

6. Dose adjustment: 
Due to its renal elimination, dose adjustment is necessary for patients with renal impairment to avoid excessive antiplatelet effects.

7. Rapid offset of action: 
The short half-life contributes to the rapid offset of the drug's antiplatelet effects after discontinuation, which can be advantageous in certain clinical situations.

It's important to note that while the elimination half-life is about 2 hours, the pharmacodynamic effects (inhibition of platelet aggregation) may persist for a longer duration, typically returning to near baseline levels within 4-8 hours after discontinuation in patients with normal renal function.