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L-Alanyl-L-Glutamine (also called Ala-Gln or Sustamine) is a dipeptide made from two amino acids: L-alanine and L-glutamine. It is a stable form of glutamine that is easier to absorb and more resistant to breakdown, making it a popular supplement in medical, sports, and wellness fields. 

Key Uses of L-Alanyl-L-Glutamine  

1. Improves Muscle Recovery and Performance  
   - Athletes and fitness enthusiasts take Ala-Gln to reduce muscle fatigue and enhance recovery after intense physical activity.  
   - It helps maintain plasma glutamine levels, which can drop during prolonged exercise, leading to fatigue and decreased endurance.  
   - It supports hydration by promoting water absorption in cells.

2. Supports Gut Health  
   - L-Alanyl-L-Glutamine plays a role in intestinal cell maintenance and repair.  
   - It can be used in treating intestinal permeability (leaky gut) and supports patients undergoing chemotherapy or suffering from inflammatory bowel diseases (IBD), such as Crohn’s disease.

3. Enhances Immune System Function  
   - Glutamine is critical for the functioning of immune cells like lymphocytes and macrophages.  
   - Ala-Gln is often given to hospitalized patients (e.g., those undergoing surgery or trauma) to support immune function and reduce infection risks.

4. Parenteral and Enteral Nutrition Support  
   - In clinical settings, Ala-Gln is used in IV (parenteral) nutrition for critically ill patients who are unable to eat.  
   - It improves nitrogen balance and prevents muscle wasting in people with severe illness, injury, or malnutrition.

5. Prevents Muscle Loss in Catabolic Conditions  
   - It is used to combat muscle atrophy caused by diseases, extended bed rest, or aging.  
   - By supporting protein synthesis, it helps preserve muscle mass in patients with chronic illnesses or those recovering from surgery.

 Mechanism of Action  

- L-Glutamine provides fuel for cells in the immune system and intestines.  
- L-Alanine improves water and electrolyte absorption, enhancing hydration and nutrient transport.  
- Together, the dipeptide form ensures more efficient absorption and stability compared to free glutamine alone.

 Common Forms and Dosage  

- Powders and capsules for athletes  
- IV infusions in clinical settings  
- Often included in oral rehydration solutions (ORS) for better hydration and nutrient uptake  

The dosage depends on the intended use:  

- Athletic performance: ~5-10 grams per day  
- Medical use: Based on body weight and the severity of the condition  
  
L-Alanyl-L-Glutamine is a versatile supplement beneficial for athletes, patients recovering from illness, and individuals with digestive or immune challenges. Whether used to boost muscle recovery or support immune function, it offers enhanced absorption and reliability over regular glutamine supplements. 

Would you like to explore its role further in a specific condition or context?