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Dextran 40 is a polysaccharide used primarily as a volume expander in medical settings. While it can be beneficial for certain conditions, it may also cause side effects. Common side effects include:

1. Allergic Reactions: 
Some individuals may experience allergic reactions, which can include itching, rash, or difficulty breathing.

2. Hypotension: 
Rapid infusion of dextran can lead to low blood pressure.

3. Fluid Overload: 

This can occur if too much dextran is administered, leading to symptoms like edema (swelling), dyspnea (difficulty breathing), or heart failure in susceptible individuals.

4. Altered Blood Coagulation: 
Dextran can affect platelet function and coagulation profiles, potentially increasing bleeding risk.

5. Nausea and Vomiting: 
Some patients may experience gastrointestinal discomfort.

6. Renal Impairment: 
In rare cases, dextran can contribute to kidney problems, especially in individuals with pre-existing renal issues.

7. Headache: 
Some users report headaches following administration.

It's important to monitor for these side effects during and after administration, and any unusual symptoms should be reported to a healthcare provider. Always consult with a healthcare professional for personalized medical advice.